| Rank |
Date |
Event |
Location |
Fatalities |
| 1 |
Sep. 11, 2001 |
The World Trade Center |
New York, NY |
2,666 (2) |
| 2 |
Dec. 30, 1903 |
Iroquois Theatre |
Chicago, IL |
602 |
| 3 |
Nov. 28, 1942 |
Cocoanut Grove night club |
Boston, MA |
492 |
| 4 |
Apr. 21, 1930 |
Ohio State Penitentiary |
Columbus, OH |
320 |
| 5 |
Mar. 18, 1937 |
Consolidated School gas explosion |
New London, TX |
294 |
| 6 |
Dec. 5, 1876 |
Conway's Theatre |
Brooklyn, NY |
285 |
| 7 |
Apr. 23, 1940 |
Rhythm Club |
Natchez, MS |
207 |
| 8 |
Mar. 4, 1908 |
Lakeview Grammar School |
Collinwood, OH |
175 |
| 9 |
Jan. 12, 1908 |
Rhodes Opera House |
Boyertown, PA |
170 |
| 10 |
Jul. 6, 1944 |
Ringling Brothers Barnum & Bailey Circus |
Hartford, CT |
168 |
| 10 |
Apr. 19, 1995 |
Alfred P. Murrah Federal Building |
Oklahoma City, OK |
168 |
| 12 |
May 28, 1977 |
Beverly Hills Supper Club |
Southgate, KY |
165 |
| 13 |
Mar. 25, 1911 |
Triangle Shirtwaist Company |
New York, NY |
146 |
| 14 |
Apr. 10, 1917 |
Eddystone Ammunition Company plant explosion |
Eddystone, PA |
133 |
| 15 |
May 15, 1929 |
Cleveland Clinic Hospital |
Cleveland, OH |
125 |
| 16 |
Dec. 7, 1946 |
Winecoff Hotel |
Atlanta, GA |
119 |
| 17 |
Feb. 20, 2003 |
The Station Nightclub |
W. Warwick, RI |
100 |
| 18 |
Dec. 1, 1958 |
Our Lady of the Angels School |
Chicago, IL |
95 |
| 19 |
Mar. 25, 1990 |
Happy Land Social Club |
New York, NY |
87 |
| 20 |
Nov. 21, 1980 |
MGM Grand Hotel |
Las Vegas, NV |
85 |
|